由意昂2平台基礎醫學院楊寶學教授主編的《Aquaporins》一書已由Springer出版社正式出版發行🚯。來自中國、美國🪱、日本等11個國家的水通道研究領域的專家學者參與了撰寫。該書系統介紹了近30年來水通道蛋白（Aquaporins🧑🏽‍🚀，AQP）領域的研究進展。全書共分18章，其內容包括水通道的分子生物學🛂、水通道的進化過程、水通道轉運特性🧕🏻、水通道與腺體分泌、神經系統的水通道🪼🧔🏻‍♀️、心血管系統的水通道🧑🏿‍🎨🤦🏻‍♂️、呼吸系統的水通道、消化系統的水通道👩🏽‍🦱🤘🏿、泌尿系統的水通道、生殖系統的水通道、皮膚的水通道、眼的水通道、胚胎發育與水通道🚊、尿崩症、水通道和肥胖、水通道作為治療靶點🟧、具有水通透性的其他膜通道和水通透性測定方法等。

　　水通道蛋白是一組特異性通透水的膜通道蛋白。該家族共有13個成員（AQP0~AQP12），包括單純通透水的水通道和通透水及甘油等小分子的水甘油通道。水通道廣泛表達於腎臟🦹‍♀️、紅細胞⛄️、腦🧑‍🤝‍🧑🤱🏻、眼👐、心臟、血管、肺🍄、肝臟🏐、腸道🤖🧑‍🦯‍➡️、膀胱、輸尿管、睾丸🤽‍♀️、腺體等多個組織器官。水通道基因敲除小鼠模型研究和臨床流行病學調查發現，水通道功能缺陷可導致尿崩症、幹眼症🧅、幹皮症等病理改變🧛🏻‍♀️。研究還發現，水通道功能性抑製可減緩腦水腫和腫瘤的進展，提示水通道蛋白可作為新的藥物靶點，其抑製劑有可能研發成為新型治療腦水腫和腫瘤的藥物。以水通道蛋白為靶點的藥物發現近年來正逐步成為該領域的研發熱點，水通道的生理學功能研究、藥物靶點確認和相關藥物篩選模型在不斷發展之中。

　　延伸閱讀：

　　施普林格（Springer）出版社是全球最大的學術與科技圖書出版社♢，全球三大學術期刊出版社之一。Springer出版的《Advances in Experimental Medicine and Biology》系列叢書，始終專註於介紹和推廣實驗醫學和生物學及其相關領域的最新研究進展。所有章節均收錄於MEDLINE/Pubmed。《Aquaporins》為該系列叢書的第969卷🍻。

　　主編楊寶學教授現為意昂2平台基礎醫學院藥理學系主任，天然藥物及仿生藥物國家重點實驗室PI，中國藥理學會理事，中國藥理學會腎臟藥理專業委員會主任委員🔬，《生理學研究》主編。主要研究領域為腎臟藥理學🤢。在研項目包括國家自然科學基金重點項目👨‍👨‍👧‍👦、重點國際合作項目、NSFC/RGC聯合科研基金項目、科技部國際科技合作專項等。已發表SCI論文115篇，2014-2016年連續3年入選愛思唯爾中國高被引學者（Most Cited Chinese Researchers）榜單。主編《Urea Transporters》、《藥理學》🌙，參編專著和教材10余部🥷🏿。申報專利9項。

　　精裝本🥅：ISBN 978-94-024-1055-6

　　電子版：ISBN 978-94-024-1057-0

　　下載鏈接⛹🏻‍♂️：http://link.springer.com/book/10.1007/978-94-024-1057-0

　　出版社對該書的介紹原文📷：

　　About this book

　　Covers research advances in the study of aquaporins for near 30 years

　　Provides a systematic and comprehensive insight into aquaporins

　　Introduces physiological and pharmaceutical aspects of aquaporins  

　　Written by experts from 11 countries in this field

　　The mechanisms and physiological functions of water transport across biological membranes are subjects of long-standing interest. Recent advances in the molecular biology and physiology of water transport have yielded new insights into how and why water moves across cell membranes. Aquaporins (AQPs) are a group of water channel proteins that are specifically permeable to water and some other small molecules, such as glycerol, urea, etc. Thirteen water channel proteins (AQP0 – AQP12) have been cloned, and gene organization, protein crystal structure, expression localization and physiological functions of some AQPs have been studied and determined. In recent years, the studies in aquaporin knockout mouse models suggest that aquaporins may be involved in some disease development and be useful targets for drug discovery of selective inhibitors. Our aim in writing this book is to stimulate further research in new directions by providing novel provocative insights into further mechanisms and physiological significance of water and some small molecule transport in mammals.

　　This book provides a state-of-the-art report on what has been learned recently about aquaporins and where the field is going. Although some older work is cited, the main focus of this book is on advances made over the past 30 years on the biophysics, genetics, protein structure, molecular biology, physiology, pathophysiology and pharmacology of aquaporins in mammalian cell membranes. It is likely that advances in understanding molecular biology and physiology of aquaporins will yield new insights into biology and medicine.

　　Keywords 😇？Membrane transporter - Transporter protein –Water channel - Aquaporin – Water transport

　　Related subjects 🫰🏻？Cell Biology- Human Genetics- Human Physiology- Pharmacology & Toxicology

　　（基礎醫學院）

編輯📄：韓娜